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Showing posts from September, 2017

Scientists propose novel therapy to lessen risk of obesity-linked disease

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The picture on the appropriate exhibits fibrinogen deposits (pink areas) which have accrued within the white adipose tissue of a mouse fed a 60 p.c high-fat food plan. The picture on the left is tissue from a management mouse on a daily food plan. Researchers report within the Journal of Scientific Investigation they uncovered a beforehand unknown molecular hyperlink within the physique that drives weight problems and irritation, that are linked to heart problems, sort 2 diabetes, fatty liver illness and several other cancers. Credit score: Cincinnati Kids's With weight problems associated sicknesses a worldwide pandemic, researchers suggest within the  Journal of Scientific Investigation  utilizing a blood thinner to focus on molecular drivers of continual metabolic irritation in individuals consuming high-fat diets to restrict weight acquire and illness. In a examine printed on-line July 24, a multi-institutional scientific workforce led by C...

A new path toward preventing obesity

Professor of Psychology Jon Maner found that people who had an unpredictable childhood tended to overeat, while those who experienced a stable childhood did not. The study was published in the journal  Proceedings of the National Academy of Sciences . "Experiencing an unpredictable environment in childhood sensitizes people to the idea that it's difficult to plan for the future because if you don't know what's around the next corner, you live for the now," Maner said. "They end up focusing on short-term rather than long-term goals and they're not good at delaying gratification." Past research has confirmed a clear link between low socioeconomic status and obesity, but those studies have not clearly identified the root causes of the problem. That research has generally concluded too much stress in families can lead to a wide variety of negative outcomes for children when they grow up. This new research uses an important, well-established persp...

Mediterranean-style diets linked to better brain function in older adults

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The Mediterranean food regimen is wealthy in fruits, greens, entire grains, beans, potatoes, nuts, olive oil and fish. Credit score: © Gorilla / Fotolia Consuming meals included in two wholesome diets -- the Mediterranean or the MIND food regimen -- is linked to a decrease threat for reminiscence difficulties in older adults, in accordance with a examine printed within the  Journal of the American Geriatrics Society . The Mediterranean food regimen is wealthy in fruits, greens, entire grains, beans, potatoes, nuts, olive oil and fish. Processed meals, fried and quick meals, snack meals, crimson meat, poultry and whole-fat dairy meals are occasionally eaten on the Mediterranean food regimen. The MIND food regimen is a model of the Mediterranean food regimen that features 15 sorts of meals. Ten are thought-about "brain-healthy:" inexperienced leafy greens, different greens, nuts, berries, beans, entire grains, seafood, poultry, olive oil, and wine. 5 are...

Diet quality matters not just quantity in mid-to-late-adulthood

The study examined close to 2,000 participants of the Multiethnic Cohort living in Hawaii and Los Angeles from five ethnic groups (White, African American, Native Hawaiian, Japanese American and Latino). The participants completed food frequency questionnaires at cohort entry from 1993-96 and at clinic visits in 2013-2016. Participants also underwent whole-body DXA and abdominal MRI scans. All four science-based diet quality scores predicted lower VAT and NAFL. Individuals with the best (highest) diet quality scores were 35-59% less likely to have high VAT and were also 22-43% less likely to have NAFL than those with the lowest scores after accounting for total body fat. A long term healthy, quality diet can reduce the risk of cardiometabolic conditions. Gertraud Maskarinec, MD, PhD, Professor of Epidemiology at University of Hawaii Cancer Center said, "The message that diet quality, not just quantity, matters is important for everyone who wants to maintain both a healthy ...

Delaying bariatric surgery until higher weight may result in poorer outcomes

It is estimated that more than 34 percent of adults in the United States are classified as obese, with a BMI of 30 or greater. Achieving a body mass index of less than 30 is an important goal of bariatric surgery, given the increased risk for weight-related health conditions and death with a BMI above this level. Oliver A. Varban, M.D., of the University of Michigan Health Systems, Ann Arbor and colleagues conducted a study to identify predictors for achieving a BMI of less than 30 after bariatric surgery. The researchers examined data for a total of 27,320 adults who underwent bariatric surgery in Michigan between June 2006 and May 2015. A total of 9,713 patients (36 percent) achieved a BMI of less than 30 at 1 year after bariatric surgery. A significant predictor for achieving this goal was a preoperative BMI of less than 40. Patients who had the surgical procedure of sleeve gastrectomy , gastric bypass, or duodenal switch were more likely to achieve a BMI of less than 30 compa...

Opting for weight-loss surgery at lower BMIs may be best for patients' health

A large new study shows that only one in three patients who have the operation succeed in getting their body-mass index below 30, the cutoff for obesity, in the first year. But the odds of achieving this goal were much higher for those who had their weight-loss operation while they were still below the "morbid obesity" BMI level of 40. On the other end of the spectrum, less than 9 percent of those who went into surgery with a BMI above 50 got down to 30 or below in the first year. Getting down to a BMI under 30 also brought patients much better odds of escaping weight-related health risks. Those who hit this level were much more likely to report that they'd stopped taking medication to control high blood pressure, blood sugar and cholesterol, and achieved remission of an obesity-linked breathing condition called sleep apnea. In all, 92 percent of those who hit a BMI under 30 in the first year said they were highly satisfied with their decision to have surgery, co...

Walnuts may promote health by changing gut bacteria

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Walnuts. Credit score: © Tim UR / Fotolia Analysis led by Lauri Byerley, PhD, RD, Analysis Affiliate Professor of Physiology at LSU Well being New Orleans Faculty of Medication, has discovered that walnuts within the weight loss program change the make-up of micro organism within the intestine, which suggests a brand new manner walnuts could contribute to higher well being. The findings are printed in  The Journal of Dietary Biochemistry obtainable on-line. "Walnuts have been known as a 'superfood' as a result of they're wealthy within the omega-Three fatty acid, alpha-linoleic acid and fiber, they usually comprise one of many highest concentrations of antioxidants," notes Dr. Byerley. "Now, an extra superfood advantage of walnuts could also be their useful modifications to the intestine microbiota." Working in a rodent mannequin, the analysis group added walnuts to the weight loss program of 1 group. The weight loss program of the ...

Green tea ingredient may ameliorate memory impairment, brain insulin resistance, and obesity

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Inexperienced tea. Credit score: © KMNPhoto / Fotolia A examine printed on-line in  The FASEB Journal , involving mice, means that EGCG (epigallocatechin-Three-gallate), probably the most plentiful catechin and biologically lively part in inexperienced tea, may alleviate high-fat and high-fructose (HFFD)-induced insulin resistance and cognitive impairment. Earlier analysis pointed to the potential of EGCG to deal with a wide range of human illnesses, but till now, EGCG's influence on insulin resistance and cognitive deficits triggered within the mind by a Western eating regimen remained unclear. "Inexperienced tea is the second most consumed beverage on the planet after water, and is grown in no less than 30 nations," mentioned Xuebo Liu , Ph.D., a researcher on the Faculty of Meals Science and Engineering, Northwest A&F College, in Yangling, China. "The traditional behavior of ingesting inexperienced tea could also be a extra acceptable vario...

Hunger-controlling brain cells may offer path for new obesity drugs

We have identified two new populations of cells in the brain that potently regulate appetite," says Alexander Nectow, first author of the paper, published in  Cell  on July 27. The two types of cells, located in a part of the brainstem called the dorsal raphe nucleus, are potential targets for new drugs to treat obesity by controlling the hunger signals that drive the search for an d consumption of food. The new findings are the latest evidence that eating is a complex biological behavior mediated by multiple sites in the brain. They also offer a possible solution to a problem that has dogged previous efforts to address obesity at the neuronal level. In 1994, Jeffrey Friedman, Marilyn M. Simpson Professor and head of Rockefeller's Laboratory of Molecular Genetics, launched a new era in obesity research by discovering a hormone called leptin, which acts on neurons in the brain's hypothalamus region to suppress hunger. Injections of the hormone have been shown to promo...

Dulled taste may prompt more calories on path to obesity

"We found that the more people lost sensitivity to sweetness, the more sugar they wanted in their foods," said lead author Robin Dando, assistant professor of food science, whose research has been published online by the journal  Appetite . Nutritionists, researchers and doctors have long suspected a connection between diminished taste sensitivity and obesity, but no one had tested if losing taste altered intake. In his research, Dando temporarily dulled the taste buds of study participants and had them sample foods of varying sugar concentrations. For the blind tests, the researchers provided participants with an herbal tea with low, medium or high concentrations of a naturally occurring herb, Gymnema Sylvestre, which is known to temporarily block sweet receptors. During the testing, participants added their favored levels of sweetness to bland concoctions. Without realizing it, they gravitated to 8 to 12 percent sucrose. Soft drinks are generally around 10 percent s...

Exercise in early life has long-lasting benefits

The research team compared the bone health and metabolism of rats across different diet and exercise conditions, zeroing in on messenger molecules that signal the activity of genes in bone marrow. Rats were either given a high-fat diet and a wheel for extra exercise in their cage, a high-fat diet but no wheel, or a regular diet and no wheel. In the rats given a high-fat diet and an exercise wheel, the early extra physical activity caused inflammation-linked genes to be turned down. High-fat diets early in life are known to turn up, or increase the activity of other genes that cause inflammation. Inflammation is the body's natural self-protective response to acute infection or injury, but the ongoing, low-grade inflammation linked to high-fat diets can harm cells and tissues and raise the risk of obesity, heart disease, cancer and other diseases. Exercise also altered the way the rats' bones metabolised energy from food, changing energy pathways that disrupt the body'...